Drug interactions
Budesonide-formoterol + Lefamulin
Severity: Moderate
Budesonide-formoterol and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval and formoterol may add to the effect, especially with low potassium. This raises the risk of torsades de pointes in predisposed patients.
What this interaction means in plain words
Budesonide-formoterol and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation, with beta-agonist induced hypokalemia.
What to do
Check ECG and correct potassium and magnesium if the patient has QT risk factors. Choose a different antibiotic in patients with known QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Budesonide-formoterol with Lefamulin?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lefamulin can prolong the QT interval and formoterol may add to the effect, especially with low potassium. This raises the risk of torsades de pointes in predisposed patients.
How serious is the interaction between Budesonide-formoterol and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium if the patient has QT risk factors. Choose a different antibiotic in patients with known QT prolongation.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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