Drug interactions
Budesonide-formoterol + Methadone
Severity: Moderate
Budesonide-formoterol and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both methadone and high-dose or systemically absorbed beta-2 agonists such as formoterol can prolong the QTc interval. Together they may add to the risk of torsades de pointes, especially in patients with other risk factors such as hypokalemia, cardiac disease or other QT-prolonging drugs.
What this interaction means in plain words
Budesonide-formoterol and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Methadone belongs to Musculoskeletal.
Why it happens
Additive QTc prolongation through methadone hERG channel blockade and beta-2 agonist-related repolarization changes and hypokalemia.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and monitor QTc after starting or changing doses. Correct potassium and magnesium abnormalities and avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Budesonide-formoterol and Methadone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Budesonide-formoterol
Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Budesonide-formoterol with Methadone?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both methadone and high-dose or systemically absorbed beta-2 agonists such as formoterol can prolong the QTc interval. Together they may add to the risk of torsades de pointes, especially in patients with other risk factors such as hypokalemia, cardiac disease or other QT-prolonging drugs.
How serious is the interaction between Budesonide-formoterol and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and monitor QTc after starting or changing doses. Correct potassium and magnesium abnormalities and avoid adding further QT-prolonging drugs.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
