Drug interactions
Budesonide-formoterol + Selpercatinib
Severity: Moderate
Budesonide-formoterol and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib prolongs the QT interval, and formoterol at high doses can also affect repolarization and cause hypokalemia. Together they may increase the risk of QT prolongation and ventricular arrhythmia, particularly in patients with other risk factors.
What this interaction means in plain words
Budesonide-formoterol and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Budesonide-formoterol belongs to Respiratory; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation, with formoterol-induced hypokalemia potentially increasing arrhythmia susceptibility.
What to do
Obtain a baseline ECG and correct potassium and magnesium before and during therapy. Re-check the ECG if symptoms occur or other QT-prolonging drugs are added.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Budesonide-formoterol
Other interactions of Selpercatinib
Frequently asked questions
Can I take Budesonide-formoterol with Selpercatinib?
MediHelp rates the interaction as moderate. Budesonide-formoterol and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib prolongs the QT interval, and formoterol at high doses can also affect repolarization and cause hypokalemia. Together they may increase the risk of QT prolongation and ventricular arrhythmia, particularly in patients with other risk factors.
How serious is the interaction between Budesonide-formoterol and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before and during therapy. Re-check the ECG if symptoms occur or other QT-prolonging drugs are added.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
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