Drug interactions
Budesonide-formoterol + Spironolactone
Severity: Minor
Budesonide-formoterol and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol can lower serum potassium while spironolactone tends to raise it. The effects largely offset each other, and the interaction is usually of little clinical consequence.
What this interaction means in plain words
Budesonide-formoterol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Budesonide-formoterol belongs to Respiratory; Spironolactone belongs to Cardiovascular.
Why it happens
Opposing effects on serum potassium: beta2-mediated cellular uptake versus aldosterone antagonism reducing renal potassium loss.
What to do
No adjustment is generally required. Monitor potassium periodically, especially in patients with renal impairment or heart failure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Budesonide-formoterol and Spironolactone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Budesonide-formoterol
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Budesonide-formoterol with Spironolactone?
MediHelp rates the interaction as minor. Budesonide-formoterol and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Formoterol can lower serum potassium while spironolactone tends to raise it. The effects largely offset each other, and the interaction is usually of little clinical consequence.
How serious is the interaction between Budesonide-formoterol and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is generally required. Monitor potassium periodically, especially in patients with renal impairment or heart failure.
What other medicines interact with Budesonide-formoterol?
MediHelp also lists interactions of Budesonide-formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Budesonide-formoterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
