Drug interactions
Bupivacaine + Timolol
Severity: Moderate
Bupivacaine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers may add to the cardiovascular depression seen with bupivacaine, and bupivacaine toxicity can be severe. Systemic timolol may also reduce hepatic blood flow and slow local anesthetic clearance.
What this interaction means in plain words
Bupivacaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupivacaine belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Additive myocardial depression and hypotension, with possible reduced hepatic clearance of bupivacaine.
What to do
Use the lowest effective bupivacaine dose, monitor ECG and blood pressure, and have resuscitation equipment available, especially with epidural or large-volume blocks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Bupivacaine
- Bupivacaine + Bupivacaine implant Major
- Amlodipine-benazepril + Bupivacaine Moderate
- Benazepril + Bupivacaine Moderate
- Bupivacaine + Bupivacaine liposome Moderate
- Bupivacaine + Captopril Moderate
- Bupivacaine + Dofetilide Moderate
Frequently asked questions
Can I take Bupivacaine with Timolol?
MediHelp rates the interaction as moderate. Bupivacaine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers may add to the cardiovascular depression seen with bupivacaine, and bupivacaine toxicity can be severe. Systemic timolol may also reduce hepatic blood flow and slow local anesthetic clearance.
How serious is the interaction between Bupivacaine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective bupivacaine dose, monitor ECG and blood pressure, and have resuscitation equipment available, especially with epidural or large-volume blocks.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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