Drug interactions
Buprenorphine + Darunavir
Severity: Moderate
Buprenorphine and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, especially when boosted with ritonavir or cobicistat, can modestly raise buprenorphine exposure through CYP3A4 inhibition. Clinically this may cause increased sedation or opioid effects.
What this interaction means in plain words
Buprenorphine and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Darunavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 metabolism of buprenorphine by the boosted protease inhibitor.
What to do
Monitor for sedation and opioid excess and adjust the buprenorphine dose if needed. Take particular care when the booster is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Buprenorphine with Darunavir?
MediHelp rates the interaction as moderate. Buprenorphine and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, especially when boosted with ritonavir or cobicistat, can modestly raise buprenorphine exposure through CYP3A4 inhibition. Clinically this may cause increased sedation or opioid effects.
How serious is the interaction between Buprenorphine and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and opioid excess and adjust the buprenorphine dose if needed. Take particular care when the booster is started or stopped.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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