Drug interactions
Avanafil + Darunavir
Severity: Contraindicated
Avanafil and Darunavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, particularly when boosted, inhibits CYP3A4 and increases avanafil exposure. This raises the risk of marked hypotension, syncope, visual effects and priapism.
What this interaction means in plain words
Avanafil and Darunavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Darunavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition reduces first-pass and systemic metabolism of avanafil.
What to do
Avoid avanafil with darunavir regimens; consider another agent for erectile dysfunction with dose-limited, monitored use.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Fosamprenavir Contraindicated
- Avanafil + Indinavir Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
- Darunavir + Fluticasone-salmeterol Contraindicated
Frequently asked questions
Can I take Avanafil with Darunavir?
MediHelp rates the interaction as contraindicated. Avanafil and Darunavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Darunavir, particularly when boosted, inhibits CYP3A4 and increases avanafil exposure. This raises the risk of marked hypotension, syncope, visual effects and priapism.
How serious is the interaction between Avanafil and Darunavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid avanafil with darunavir regimens; consider another agent for erectile dysfunction with dose-limited, monitored use.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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