Drug interactions
Darunavir + Ergotamine
Severity: Contraindicated
Darunavir and Ergotamine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir inhibits CYP3A4 and can raise ergotamine levels substantially. This can produce acute ergot toxicity with peripheral vasospasm and ischemia.
What this interaction means in plain words
Darunavir and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Darunavir belongs to Anti Virals; Ergotamine belongs to Central Nervous System.
Why it happens
Ritonavir or cobicistat-boosted darunavir inhibits CYP3A4, reducing ergotamine clearance.
What to do
Do not co-administer; use a non-ergot alternative for migraine.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
- Dihydroergotamine + Ergotamine Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Flibanserin Contraindicated
- Darunavir + Fluticasone-salmeterol Contraindicated
Frequently asked questions
Can I take Darunavir with Ergotamine?
MediHelp rates the interaction as contraindicated. Darunavir and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Boosted darunavir inhibits CYP3A4 and can raise ergotamine levels substantially. This can produce acute ergot toxicity with peripheral vasospasm and ischemia.
How serious is the interaction between Darunavir and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-ergot alternative for migraine.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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