Drug interactions
Buprenorphine + Ethinyl estradiol-drospirenone
Severity: Minor
Buprenorphine and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is a weak CYP3A4 inhibitor at best and is unlikely to raise buprenorphine exposure meaningfully. No clinically relevant effect has been established with this combination.
What this interaction means in plain words
Buprenorphine and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Buprenorphine belongs to Musculoskeletal; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Theoretical weak CYP3A4 inhibition; not established as clinically significant.
What to do
No routine action is needed; watch for sedation if opioid effects seem stronger than expected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Buprenorphine with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Buprenorphine and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is a weak CYP3A4 inhibitor at best and is unlikely to raise buprenorphine exposure meaningfully. No clinically relevant effect has been established with this combination.
How serious is the interaction between Buprenorphine and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; watch for sedation if opioid effects seem stronger than expected.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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