Drug interactions
Buprenorphine + Fluphenazine
Severity: Moderate
Buprenorphine and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is a sedating phenothiazine antipsychotic that can add to buprenorphine's CNS depression and hypotension. Both drugs have been linked to QT prolongation, so arrhythmia risk may increase.
What this interaction means in plain words
Buprenorphine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Fluphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive QT interval prolongation.
What to do
Monitor sedation and blood pressure, and obtain an ECG in patients with other QT risk factors. Correct potassium and magnesium abnormalities and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Buprenorphine with Fluphenazine?
MediHelp rates the interaction as moderate. Buprenorphine and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine is a sedating phenothiazine antipsychotic that can add to buprenorphine's CNS depression and hypotension. Both drugs have been linked to QT prolongation, so arrhythmia risk may increase.
How serious is the interaction between Buprenorphine and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and obtain an ECG in patients with other QT risk factors. Correct potassium and magnesium abnormalities and use the lowest effective doses.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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