Drug interactions
Buprenorphine + Letermovir
Severity: Moderate
Buprenorphine and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir can raise buprenorphine exposure through moderate inhibition of CYP3A4. Higher buprenorphine levels may cause excess sedation and respiratory depression.
What this interaction means in plain words
Buprenorphine and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4, reducing the metabolic clearance of buprenorphine.
What to do
Monitor for sedation, respiratory depression and miosis when letermovir is started. Reduce the buprenorphine dose if signs of excess opioid effect appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Buprenorphine with Letermovir?
MediHelp rates the interaction as moderate. Buprenorphine and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir can raise buprenorphine exposure through moderate inhibition of CYP3A4. Higher buprenorphine levels may cause excess sedation and respiratory depression.
How serious is the interaction between Buprenorphine and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and miosis when letermovir is started. Reduce the buprenorphine dose if signs of excess opioid effect appear.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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