Drug interactions
Buprenorphine + Lurasidone
Severity: Moderate
Buprenorphine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause greater drowsiness, dizziness and psychomotor impairment. Respiratory depression is less likely but is possible, particularly in frail patients or at higher doses.
What this interaction means in plain words
Buprenorphine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of an opioid partial agonist and a sedating atypical antipsychotic.
What to do
Start at the lowest effective doses and monitor for excessive sedation and slowed breathing, especially after dose increases. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Buprenorphine with Lurasidone?
MediHelp rates the interaction as moderate. Buprenorphine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause greater drowsiness, dizziness and psychomotor impairment. Respiratory depression is less likely but is possible, particularly in frail patients or at higher doses.
How serious is the interaction between Buprenorphine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at the lowest effective doses and monitor for excessive sedation and slowed breathing, especially after dose increases. Advise patients to avoid driving and alcohol.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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