Drug interactions
Buprenorphine + Macimorelin
Severity: Moderate
Buprenorphine and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lengthen the QT interval, and macimorelin labeling advises avoiding it with QT-prolonging drugs. Combined use may raise the risk of arrhythmia during the test.
What this interaction means in plain words
Buprenorphine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Macimorelin belongs to Endocrine.
Why it happens
Additive QT interval prolongation.
What to do
Consider an alternative growth hormone stimulation test or defer testing if buprenorphine can be safely held. Otherwise obtain an ECG and monitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Buprenorphine with Macimorelin?
MediHelp rates the interaction as moderate. Buprenorphine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lengthen the QT interval, and macimorelin labeling advises avoiding it with QT-prolonging drugs. Combined use may raise the risk of arrhythmia during the test.
How serious is the interaction between Buprenorphine and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative growth hormone stimulation test or defer testing if buprenorphine can be safely held. Otherwise obtain an ECG and monitor.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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