Drug interactions
Buprenorphine + Osimertinib
Severity: Moderate
Buprenorphine and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are associated with QT prolongation, so the combination may increase the chance of ventricular arrhythmia.
What this interaction means in plain words
Buprenorphine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Osimertinib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Check a baseline ECG and electrolytes, and monitor QTc periodically. Stop or change therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Buprenorphine with Osimertinib?
MediHelp rates the interaction as moderate. Buprenorphine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are associated with QT prolongation, so the combination may increase the chance of ventricular arrhythmia.
How serious is the interaction between Buprenorphine and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and monitor QTc periodically. Stop or change therapy if QTc becomes markedly prolonged.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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