Drug interactions
Carbamazepine + Osimertinib
Severity: Major
Carbamazepine and Osimertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can lower osimertinib exposure and may reduce its antitumor efficacy.
What this interaction means in plain words
Carbamazepine and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Carbamazepine is a strong CYP3A4 inducer and increases osimertinib clearance.
What to do
Avoid the combination and use a non-inducing anticonvulsant. If it cannot be avoided, labeling suggests increasing the osimertinib dose with close monitoring of response and tolerability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Carbamazepine with Osimertinib?
MediHelp rates the interaction as major. Carbamazepine and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine can lower osimertinib exposure and may reduce its antitumor efficacy.
How serious is the interaction between Carbamazepine and Osimertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing anticonvulsant. If it cannot be avoided, labeling suggests increasing the osimertinib dose with close monitoring of response and tolerability.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
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