Drug interactions
Amiodarone + Osimertinib
Severity: Major
Amiodarone and Osimertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combining them raises the risk of serious ventricular arrhythmia such as torsades de pointes. Risk is higher with electrolyte abnormalities or bradycardia.
What this interaction means in plain words
Amiodarone and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Osimertinib belongs to Oncology.
Why it happens
Additive QTc prolongation.
What to do
Obtain periodic ECGs and electrolytes and correct potassium and magnesium abnormalities. Consider an alternative to amiodarone, or stop osimertinib if the QTc exceeds safe limits.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Amiodarone with Osimertinib?
MediHelp rates the interaction as major. Amiodarone and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combining them raises the risk of serious ventricular arrhythmia such as torsades de pointes. Risk is higher with electrolyte abnormalities or bradycardia.
How serious is the interaction between Amiodarone and Osimertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain periodic ECGs and electrolytes and correct potassium and magnesium abnormalities. Consider an alternative to amiodarone, or stop osimertinib if the QTc exceeds safe limits.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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