Drug interactions
Anagrelide + Osimertinib
Severity: Major
Anagrelide and Osimertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QTc interval, and anagrelide may add to it. The combination may raise the risk of arrhythmia, particularly in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Anagrelide and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Osimertinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid if feasible. If used together, obtain periodic ECGs and electrolytes and correct abnormalities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Anagrelide with Osimertinib?
MediHelp rates the interaction as major. Anagrelide and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Osimertinib can prolong the QTc interval, and anagrelide may add to it. The combination may raise the risk of arrhythmia, particularly in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Anagrelide and Osimertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if feasible. If used together, obtain periodic ECGs and electrolytes and correct abnormalities.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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