Drug interactions
Buprenorphine + Perphenazine
Severity: Moderate
Buprenorphine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a sedating phenothiazine, so combined use with buprenorphine increases drowsiness, hypotension and CNS depression. Both agents can prolong the QT interval, which adds to the risk of arrhythmia.
What this interaction means in plain words
Buprenorphine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive QT prolongation.
What to do
Use the lowest effective doses and consider a baseline ECG in patients with cardiac risk factors. Keep potassium and magnesium within the normal range and monitor for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Buprenorphine with Perphenazine?
MediHelp rates the interaction as moderate. Buprenorphine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a sedating phenothiazine, so combined use with buprenorphine increases drowsiness, hypotension and CNS depression. Both agents can prolong the QT interval, which adds to the risk of arrhythmia.
How serious is the interaction between Buprenorphine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and consider a baseline ECG in patients with cardiac risk factors. Keep potassium and magnesium within the normal range and monitor for sedation.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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