Drug interactions
Buprenorphine + Solifenacin
Severity: Moderate
Buprenorphine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, although buprenorphine's effect is modest and mainly seen with transdermal or high doses. Combined use may modestly increase arrhythmia risk, and anticholinergic constipation may also be worsened.
What this interaction means in plain words
Buprenorphine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Monitor the ECG in patients with other QT risk factors and keep electrolytes normal; watch for constipation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Frequently asked questions
Can I take Buprenorphine with Solifenacin?
MediHelp rates the interaction as moderate. Buprenorphine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, although buprenorphine's effect is modest and mainly seen with transdermal or high doses. Combined use may modestly increase arrhythmia risk, and anticholinergic constipation may also be worsened.
How serious is the interaction between Buprenorphine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG in patients with other QT risk factors and keep electrolytes normal; watch for constipation.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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