Drug interactions
Buprenorphine + Tazemetostat
Severity: Moderate
Buprenorphine and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may reduce buprenorphine concentrations. This could result in diminished analgesic effect or emerging withdrawal.
What this interaction means in plain words
Buprenorphine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Tazemetostat belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 metabolism of buprenorphine.
What to do
Monitor for reduced analgesia or withdrawal symptoms and increase the buprenorphine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Buprenorphine with Tazemetostat?
MediHelp rates the interaction as moderate. Buprenorphine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may reduce buprenorphine concentrations. This could result in diminished analgesic effect or emerging withdrawal.
How serious is the interaction between Buprenorphine and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced analgesia or withdrawal symptoms and increase the buprenorphine dose if needed.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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