Drug interactions
Buprenorphine + Tipranavir
Severity: Moderate
Buprenorphine and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir with ritonavir is a potent CYP3A4 inhibitor and may raise buprenorphine levels, increasing the risk of sedation and respiratory depression. Tipranavir also has inducing effects, so the net effect can vary.
What this interaction means in plain words
Buprenorphine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Buprenorphine belongs to Musculoskeletal; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated buprenorphine metabolism, with possible mixed induction.
What to do
Monitor for oversedation, respiratory depression and opioid toxicity, and reduce the buprenorphine dose if signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buprenorphine
- Alvimopan + Buprenorphine Contraindicated
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Buprenorphine + Olanzapine / samidorphan Contraindicated
- Buprenorphine + Phenelzine Contraindicated
- Buprenorphine + Pimozide Contraindicated
- Buprenorphine + Thioridazine Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Buprenorphine with Tipranavir?
MediHelp rates the interaction as moderate. Buprenorphine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir with ritonavir is a potent CYP3A4 inhibitor and may raise buprenorphine levels, increasing the risk of sedation and respiratory depression. Tipranavir also has inducing effects, so the net effect can vary.
How serious is the interaction between Buprenorphine and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, respiratory depression and opioid toxicity, and reduce the buprenorphine dose if signs appear.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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