Drug interactions
Colchicine + Tipranavir
Severity: Contraindicated
Colchicine and Tipranavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, inhibits CYP3A4 and P-glycoprotein and can substantially increase colchicine concentrations. This raises the risk of severe or fatal colchicine toxicity, especially in renal or hepatic impairment.
What this interaction means in plain words
Colchicine and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Colchicine belongs to Genitourinary; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4 and P-glycoprotein, decreasing colchicine clearance.
What to do
Avoid in patients with renal or hepatic impairment. Otherwise use an alternative if possible, or reduce the colchicine dose per labeling and monitor closely for toxicity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Dronedarone + Tipranavir Contraindicated
Frequently asked questions
Can I take Colchicine with Tipranavir?
MediHelp rates the interaction as contraindicated. Colchicine and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir, given with ritonavir, inhibits CYP3A4 and P-glycoprotein and can substantially increase colchicine concentrations. This raises the risk of severe or fatal colchicine toxicity, especially in renal or hepatic impairment.
How serious is the interaction between Colchicine and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with renal or hepatic impairment. Otherwise use an alternative if possible, or reduce the colchicine dose per labeling and monitor closely for toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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