Drug interactions
Buprenorphine buccal + Clomipramine
Severity: Major
Buprenorphine buccal and Clomipramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and buprenorphine adds sedation and respiratory depression to clomipramine's sedative effects. Serotonergic effects are also possible.
What this interaction means in plain words
Buprenorphine buccal and Clomipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and CNS depression, with potential serotonergic activity.
What to do
Obtain an ECG if other QT risks exist and monitor for sedation and respiratory depression. Use the lowest effective doses.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Clomipramine?
MediHelp rates the interaction as major. Buprenorphine buccal and Clomipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and buprenorphine adds sedation and respiratory depression to clomipramine's sedative effects. Serotonergic effects are also possible.
How serious is the interaction between Buprenorphine buccal and Clomipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG if other QT risks exist and monitor for sedation and respiratory depression. Use the lowest effective doses.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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