Drug interactions
Buprenorphine buccal + Dasatinib
Severity: Moderate
Buprenorphine buccal and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib and buprenorphine can both lengthen the QT interval, and the buccal formulation gives meaningful systemic exposure. The combination may increase the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Buprenorphine buccal and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Check a baseline ECG and electrolytes and monitor the QTc during co-therapy. Consider dose reduction or an alternative analgesic if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Buprenorphine buccal with Dasatinib?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib and buprenorphine can both lengthen the QT interval, and the buccal formulation gives meaningful systemic exposure. The combination may increase the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Buprenorphine buccal and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and monitor the QTc during co-therapy. Consider dose reduction or an alternative analgesic if the QTc becomes markedly prolonged.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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