Drug interactions
Buprenorphine buccal + Lurasidone
Severity: Major
Buprenorphine buccal and Lurasidone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine and other CNS depressants such as antipsychotics can cause additive sedation and respiratory depression. The combination can cause profound sedation, and rarely coma or death, mostly with higher doses or other sedatives.
What this interaction means in plain words
Buprenorphine buccal and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression from opioid partial agonism and antipsychotic sedation.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression, especially at initiation and after dose changes. Counsel patients to avoid alcohol and other sedatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Latuda 18.5mg film-coated tablets - SmPC sections 4.3/4.5 (names the partner; "such as buprenorphine/opioids") — electronic medicines compendium (UK SmPC)
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Lurasidone?
MediHelp rates the interaction as major. Buprenorphine buccal and Lurasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Buprenorphine and other CNS depressants such as antipsychotics can cause additive sedation and respiratory depression. The combination can cause profound sedation, and rarely coma or death, mostly with higher doses or other sedatives.
How serious is the interaction between Buprenorphine buccal and Lurasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression, especially at initiation and after dose changes. Counsel patients to avoid alcohol and other sedatives.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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