Drug interactions
Buprenorphine buccal + Moxifloxacin
Severity: Major
Buprenorphine buccal and Moxifloxacin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine buccal film is associated with dose-related QT prolongation, and moxifloxacin also prolongs QT. Combined use may increase the risk of torsades de pointes.
What this interaction means in plain words
Buprenorphine buccal and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Choose an alternative antibiotic where possible. Otherwise monitor ECG and electrolytes, especially in higher-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Moxifloxacin?
MediHelp rates the interaction as major. Buprenorphine buccal and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Buprenorphine buccal film is associated with dose-related QT prolongation, and moxifloxacin also prolongs QT. Combined use may increase the risk of torsades de pointes.
How serious is the interaction between Buprenorphine buccal and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose an alternative antibiotic where possible. Otherwise monitor ECG and electrolytes, especially in higher-risk patients.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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