Drug interactions
Buprenorphine buccal + Voriconazole
Severity: Moderate
Buprenorphine buccal and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combining them may increase the risk of torsades de pointes. Voriconazole may also raise buprenorphine levels through CYP3A4 inhibition, increasing sedation and respiratory depression.
What this interaction means in plain words
Buprenorphine buccal and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation plus CYP3A4 inhibition reducing buprenorphine metabolism.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities before combining. Monitor for QT prolongation, sedation and respiratory depression, and reduce the buprenorphine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Buprenorphine buccal with Voriconazole?
MediHelp rates the interaction as moderate. Buprenorphine buccal and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combining them may increase the risk of torsades de pointes. Voriconazole may also raise buprenorphine levels through CYP3A4 inhibition, increasing sedation and respiratory depression.
How serious is the interaction between Buprenorphine buccal and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities before combining. Monitor for QT prolongation, sedation and respiratory depression, and reduce the buprenorphine dose if needed.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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