Drug reference
voriconazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Anti Fungals (Azoles)
Mechanism of action
Triazole antifungal agent: Acts by inhibition of fungal cytochrome P-450 and sterol C-14 alpha-demethylation; decreases ergosterol synthesis and inhibits fungal cell membrane formation
Common side effects
- Visual changes (photophobia, color changes)
- Hypotension
- Hypertension
- Vasodilation
- Tachycardia
- Peripheral edema
Contraindications
- Patients with galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption
- Coadministration with cisapride, astemizole, cisapride, lurasidone, pimozide, quinidine, ivabradine, efavirenz (doses ≥400 mg/day), ritonavir (high dose – 400 mg q12hr), ergot alkaloids (ergotamine, dihydroergotamine), rifabutin, sirolimus, St. John’s wort, rifampin, carbamazepine, barbiturates, na…
- Coadministration with venetoclax at initiation and during ramp-up phase in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma
- Hypersensitivity
- Do not give IV bolus
Known interactions (18)
- avanafil + voriconazole Contraindicated
- dronedarone + voriconazole Contraindicated
- efavirenz + voriconazole Contraindicated
- ergotamine + voriconazole Contraindicated
- flibanserin + voriconazole Contraindicated
- rifampin + voriconazole Contraindicated
- carbamazepine + voriconazole Major
- chloroquine + voriconazole Major
- colchicine + voriconazole Major
- enzalutamide + voriconazole Major
- erythromycin + voriconazole Major
- everolimus + voriconazole Major
- ondansetron + voriconazole Major
- sirolimus + voriconazole Major
- tacrolimus + voriconazole Major
- alfuzosin + voriconazole Moderate
- Piperacillin + voriconazole Moderate
- Piperacillin/Tazobactam + voriconazole Moderate
Related conditions
Frequently asked questions
What drug class is voriconazole?
voriconazole belongs to: Anti Fungals.
How does voriconazole work?
Triazole antifungal agent: Acts by inhibition of fungal cytochrome P-450 and sterol C-14 alpha-demethylation; decreases ergosterol synthesis and inhibits fungal cell membrane formation
What are the common side effects of voriconazole?
Visual changes (photophobia, color changes), Hypotension, Hypertension, Vasodilation, Tachycardia, Peripheral edema
Which drugs interact with voriconazole?
avanafil, dronedarone, efavirenz, ergotamine, flibanserin, rifampin, carbamazepine, chloroquine, colchicine, enzalutamide, erythromycin, everolimus, ondansetron, sirolimus, tacrolimus
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