Drug interactions
Buprenorphine long-acting + Clomipramine
Severity: Major
Buprenorphine long-acting and Clomipramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting buprenorphine injection combined with clomipramine can add to QT prolongation and CNS depression. Because buprenorphine exposure persists for weeks, effects cannot be quickly reversed.
What this interaction means in plain words
Buprenorphine long-acting and Clomipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation and CNS depression.
What to do
Monitor for sedation and respiratory depression and obtain an ECG in patients with cardiac risk factors. Use the lowest effective clomipramine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Clomipramine?
MediHelp rates the interaction as major. Buprenorphine long-acting and Clomipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Long-acting buprenorphine injection combined with clomipramine can add to QT prolongation and CNS depression. Because buprenorphine exposure persists for weeks, effects cannot be quickly reversed.
How serious is the interaction between Buprenorphine long-acting and Clomipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression and obtain an ECG in patients with cardiac risk factors. Use the lowest effective clomipramine dose.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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