Drug interactions
Buprenorphine long-acting + Clorazepate
Severity: Major
Buprenorphine long-acting and Clorazepate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concomitant benzodiazepine and long-acting injectable buprenorphine increases the risk of profound sedation, respiratory depression, coma and death. The depot gives prolonged opioid exposure.
What this interaction means in plain words
Buprenorphine long-acting and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Use together only if no alternatives exist, with the lowest clorazepate dose and shortest duration. Monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clorazepate
- Calcium / magnesium / potassium / sodium oxybates + Clorazepate Contraindicated
- Clorazepate + Sodium oxybate Contraindicated
- Alfentanil + Clorazepate Major
- Alprazolam + Clorazepate Major
- Amobarbital + Clorazepate Major
- Belladonna and opium + Clorazepate Major
Frequently asked questions
Can I take Buprenorphine long-acting with Clorazepate?
MediHelp rates the interaction as major. Buprenorphine long-acting and Clorazepate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concomitant benzodiazepine and long-acting injectable buprenorphine increases the risk of profound sedation, respiratory depression, coma and death. The depot gives prolonged opioid exposure.
How serious is the interaction between Buprenorphine long-acting and Clorazepate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only if no alternatives exist, with the lowest clorazepate dose and shortest duration. Monitor for sedation and respiratory depression.
What other medicines interact with Clorazepate?
MediHelp also lists interactions of Clorazepate with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clorazepate page.
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