Drug interactions
Buprenorphine long-acting + Dasatinib
Severity: Moderate
Buprenorphine long-acting and Dasatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have QT-prolonging potential, and long-acting buprenorphine injection maintains sustained systemic exposure that cannot be quickly withdrawn. Combined use may increase arrhythmia risk in predisposed patients.
What this interaction means in plain words
Buprenorphine long-acting and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and correct electrolytes before starting dasatinib, then monitor the QTc periodically. Weigh the cardiac risk when choosing opioid agonist therapy in patients with a prolonged QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Buprenorphine long-acting with Dasatinib?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Dasatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have QT-prolonging potential, and long-acting buprenorphine injection maintains sustained systemic exposure that cannot be quickly withdrawn. Combined use may increase arrhythmia risk in predisposed patients.
How serious is the interaction between Buprenorphine long-acting and Dasatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes before starting dasatinib, then monitor the QTc periodically. Weigh the cardiac risk when choosing opioid agonist therapy in patients with a prolonged QTc.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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