Drug interactions
Buprenorphine long-acting + Desflurane
Severity: Moderate
Buprenorphine long-acting and Desflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting injectable buprenorphine gives sustained opioid exposure with possible modest QT prolongation. Desflurane adds CNS depression and QT effects, so sedation, respiratory depression and arrhythmia risk may rise.
What this interaction means in plain words
Buprenorphine long-acting and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and possible additive QT prolongation.
What to do
Tell the anesthesia team about the depot and titrate anesthetic doses to effect. Monitor the ECG, respiration and sedation, including in recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Buprenorphine long-acting with Desflurane?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Desflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-acting injectable buprenorphine gives sustained opioid exposure with possible modest QT prolongation. Desflurane adds CNS depression and QT effects, so sedation, respiratory depression and arrhythmia risk may rise.
How serious is the interaction between Buprenorphine long-acting and Desflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about the depot and titrate anesthetic doses to effect. Monitor the ECG, respiration and sedation, including in recovery.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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