Drug interactions
Buprenorphine long-acting + Dicyclomine
Severity: Moderate
Buprenorphine long-acting and Dicyclomine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine reduces gut motility and can cause urinary retention. Added to an anticholinergic such as dicyclomine, it increases the risk of severe constipation and paralytic ileus.
What this interaction means in plain words
Buprenorphine long-acting and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive suppression of gastrointestinal and bladder smooth muscle activity through opioid and antimuscarinic actions.
What to do
Monitor bowel function and urinary retention, and use a bowel regimen as needed. Stop dicyclomine if ileus or retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Buprenorphine long-acting with Dicyclomine?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Dicyclomine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine reduces gut motility and can cause urinary retention. Added to an anticholinergic such as dicyclomine, it increases the risk of severe constipation and paralytic ileus.
How serious is the interaction between Buprenorphine long-acting and Dicyclomine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary retention, and use a bowel regimen as needed. Stop dicyclomine if ileus or retention develops.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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