Drug interactions
Buprenorphine long-acting + Eslicarbazepine
Severity: Moderate
Buprenorphine long-acting and Eslicarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine may lower buprenorphine exposure from long-acting injection, risking withdrawal or relapse. The depot dose cannot be quickly changed.
What this interaction means in plain words
Buprenorphine long-acting and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction increases buprenorphine metabolism.
What to do
Monitor for withdrawal and adequacy of buprenorphine effect, and revert to a transmucosal formulation if the dose is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Buprenorphine long-acting with Eslicarbazepine?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Eslicarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine may lower buprenorphine exposure from long-acting injection, risking withdrawal or relapse. The depot dose cannot be quickly changed.
How serious is the interaction between Buprenorphine long-acting and Eslicarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal and adequacy of buprenorphine effect, and revert to a transmucosal formulation if the dose is inadequate.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
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