Drug interactions
Buprenorphine long-acting + Gemifloxacin
Severity: Moderate
Buprenorphine long-acting and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting injectable buprenorphine provides sustained exposure with some QT-prolongation potential. With gemifloxacin the risk of arrhythmia may rise modestly.
What this interaction means in plain words
Buprenorphine long-acting and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization.
What to do
Use a non-QT-prolonging antibiotic in patients with cardiac risk factors. If both are needed, obtain an ECG and monitor electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Gemifloxacin?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-acting injectable buprenorphine provides sustained exposure with some QT-prolongation potential. With gemifloxacin the risk of arrhythmia may rise modestly.
How serious is the interaction between Buprenorphine long-acting and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antibiotic in patients with cardiac risk factors. If both are needed, obtain an ECG and monitor electrolytes.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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