Drug interactions
Buprenorphine long-acting + Haloperidol
Severity: Moderate
Buprenorphine long-acting and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and buprenorphine adds CNS and respiratory depression to haloperidol effects. The long-acting injection cannot be withdrawn quickly if problems occur.
What this interaction means in plain words
Buprenorphine long-acting and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and additive CNS depression.
What to do
Obtain a baseline ECG and monitor QTc and sedation, correcting potassium and magnesium. Prefer an antipsychotic with lower QT risk if cardiac risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Haloperidol?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and buprenorphine adds CNS and respiratory depression to haloperidol effects. The long-acting injection cannot be withdrawn quickly if problems occur.
How serious is the interaction between Buprenorphine long-acting and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and sedation, correcting potassium and magnesium. Prefer an antipsychotic with lower QT risk if cardiac risk factors are present.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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