Drug interactions
Buprenorphine long-acting + Hydrochlorothiazide-lisinopril
Severity: Minor
Buprenorphine long-acting and Hydrochlorothiazide-lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids may promote antidiuretic hormone release and can cause hypotension, which may blunt the diuretic effect and add to blood pressure lowering. The effect is usually modest.
What this interaction means in plain words
Buprenorphine long-acting and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opioid-induced ADH release opposes diuresis, and additive hypotensive effects may occur.
What to do
Monitor blood pressure, fluid status and edema, and adjust diuretic dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Buprenorphine long-acting with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as minor. Buprenorphine long-acting and Hydrochlorothiazide-lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids may promote antidiuretic hormone release and can cause hypotension, which may blunt the diuretic effect and add to blood pressure lowering. The effect is usually modest.
How serious is the interaction between Buprenorphine long-acting and Hydrochlorothiazide-lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and edema, and adjust diuretic dose if needed.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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