Drug interactions
Buprenorphine long-acting + Itraconazole
Severity: Moderate
Buprenorphine long-acting and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can affect cardiac repolarization, and itraconazole may raise buprenorphine levels via CYP3A4 inhibition. The long-acting injection cannot be quickly withdrawn if adverse effects occur.
What this interaction means in plain words
Buprenorphine long-acting and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with CYP3A4 inhibition by itraconazole increasing buprenorphine exposure.
What to do
Monitor for sedation, respiratory depression and QT-related symptoms, and obtain an ECG if risk factors exist. Choose an antifungal with less CYP3A4 inhibition if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Itraconazole?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can affect cardiac repolarization, and itraconazole may raise buprenorphine levels via CYP3A4 inhibition. The long-acting injection cannot be quickly withdrawn if adverse effects occur.
How serious is the interaction between Buprenorphine long-acting and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and QT-related symptoms, and obtain an ECG if risk factors exist. Choose an antifungal with less CYP3A4 inhibition if feasible.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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