Drug interactions
Buprenorphine long-acting + Mefloquine
Severity: Moderate
Buprenorphine long-acting and Mefloquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine has a modest QT-prolonging potential and mefloquine may add to it. Because long-acting injections cannot be quickly withdrawn, any additive effect persists for a prolonged period.
What this interaction means in plain words
Buprenorphine long-acting and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Prefer a non-QT-prolonging antimalarial. If mefloquine is needed, obtain a baseline ECG and monitor electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Mefloquine?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Mefloquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine has a modest QT-prolonging potential and mefloquine may add to it. Because long-acting injections cannot be quickly withdrawn, any additive effect persists for a prolonged period.
How serious is the interaction between Buprenorphine long-acting and Mefloquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antimalarial. If mefloquine is needed, obtain a baseline ECG and monitor electrolytes.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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