Drug interactions
Buprenorphine long-acting + Moxifloxacin
Severity: Moderate
Buprenorphine long-acting and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin prolongs QT, while long-acting buprenorphine injections give steady exposure with limited QT effect. The combined risk is modest but relevant in patients with other arrhythmia risk factors.
What this interaction means in plain words
Buprenorphine long-acting and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QT prolongation.
What to do
Monitor ECG and correct electrolytes in patients with cardiac risk factors. Consider another antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Moxifloxacin?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin prolongs QT, while long-acting buprenorphine injections give steady exposure with limited QT effect. The combined risk is modest but relevant in patients with other arrhythmia risk factors.
How serious is the interaction between Buprenorphine long-acting and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct electrolytes in patients with cardiac risk factors. Consider another antibiotic in high-risk patients.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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