Drug interactions
Buprenorphine long-acting + Ribociclib
Severity: Moderate
Buprenorphine long-acting and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both can prolong the QTc interval, so combining them may increase the risk of torsades de pointes. The long-acting injection leaves drug exposure for weeks, limiting rapid withdrawal if problems arise.
What this interaction means in plain words
Buprenorphine long-acting and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT interval prolongation.
What to do
Check baseline ECG and electrolytes, and monitor the QTc periodically during ribociclib therapy. Review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Ribociclib?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both can prolong the QTc interval, so combining them may increase the risk of torsades de pointes. The long-acting injection leaves drug exposure for weeks, limiting rapid withdrawal if problems arise.
How serious is the interaction between Buprenorphine long-acting and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and monitor the QTc periodically during ribociclib therapy. Review other QT-prolonging drugs.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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