Drug interactions
Buprenorphine long-acting + Solifenacin
Severity: Minor
Buprenorphine long-acting and Solifenacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Long-acting buprenorphine injections can modestly prolong the QT interval, and solifenacin has a dose-related QT effect. The risk is mainly in patients with other proarrhythmic factors.
What this interaction means in plain words
Buprenorphine long-acting and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive QT prolongation.
What to do
No routine action is needed; obtain an ECG and correct electrolytes in patients with QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Solifenacin
Frequently asked questions
Can I take Buprenorphine long-acting with Solifenacin?
MediHelp rates the interaction as minor. Buprenorphine long-acting and Solifenacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Long-acting buprenorphine injections can modestly prolong the QT interval, and solifenacin has a dose-related QT effect. The risk is mainly in patients with other proarrhythmic factors.
How serious is the interaction between Buprenorphine long-acting and Solifenacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; obtain an ECG and correct electrolytes in patients with QT risk factors.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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