Drug interactions
Buprenorphine long-acting + Tacrolimus
Severity: Moderate
Buprenorphine long-acting and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus and buprenorphine both have the potential to prolong the QT interval, so combined use may add to the risk of torsades de pointes. The long-acting injection gives sustained exposure that cannot be quickly withdrawn.
What this interaction means in plain words
Buprenorphine long-acting and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Check a baseline ECG and correct potassium and magnesium before starting. Monitor the QTc periodically and review other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Buprenorphine long-acting with Tacrolimus?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus and buprenorphine both have the potential to prolong the QT interval, so combined use may add to the risk of torsades de pointes. The long-acting injection gives sustained exposure that cannot be quickly withdrawn.
How serious is the interaction between Buprenorphine long-acting and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct potassium and magnesium before starting. Monitor the QTc periodically and review other QT-prolonging drugs.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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