Drug interactions
Buprenorphine subdermal implant + Clomipramine
Severity: Moderate
Buprenorphine subdermal implant and Clomipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine and clomipramine may both prolong the QT interval and both cause sedation. Combined use can increase the risk of arrhythmia, respiratory depression and serotonergic effects.
What this interaction means in plain words
Buprenorphine subdermal implant and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and CNS depression.
What to do
Monitor for sedation and respiratory depression, and obtain an ECG in patients with cardiac risk factors. Avoid additional CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Clomipramine?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Clomipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine and clomipramine may both prolong the QT interval and both cause sedation. Combined use can increase the risk of arrhythmia, respiratory depression and serotonergic effects.
How serious is the interaction between Buprenorphine subdermal implant and Clomipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, and obtain an ECG in patients with cardiac risk factors. Avoid additional CNS depressants.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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