Drug interactions
Buprenorphine subdermal implant + Crizotinib
Severity: Moderate
Buprenorphine subdermal implant and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QTc interval, though buprenorphine implant concentrations are low and steady. The additive risk is modest in most patients.
What this interaction means in plain words
Buprenorphine subdermal implant and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QTc prolongation.
What to do
Check a baseline ECG and electrolytes, and monitor QTc in patients with other arrhythmia risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Crizotinib?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QTc interval, though buprenorphine implant concentrations are low and steady. The additive risk is modest in most patients.
How serious is the interaction between Buprenorphine subdermal implant and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and monitor QTc in patients with other arrhythmia risk factors.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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