Drug interactions
Buprenorphine subdermal implant + Dronedarone
Severity: Moderate
Buprenorphine subdermal implant and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine has a modest QT effect that may add to dronedarone. Implant exposure is steady and low, so the risk is lower than with higher-dose forms.
What this interaction means in plain words
Buprenorphine subdermal implant and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and minor CYP3A4 inhibition.
What to do
Check baseline ECG and electrolytes and monitor for symptoms of arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Dronedarone?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine has a modest QT effect that may add to dronedarone. Implant exposure is steady and low, so the risk is lower than with higher-dose forms.
How serious is the interaction between Buprenorphine subdermal implant and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes and monitor for symptoms of arrhythmia.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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