Drug interactions
Buprenorphine subdermal implant + Entacapone
Severity: Minor
Buprenorphine subdermal implant and Entacapone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can cause sedation and dizziness, and entacapone may add to somnolence. The additive effect is generally modest with the low steady exposure from an implant.
What this interaction means in plain words
Buprenorphine subdermal implant and Entacapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects.
What to do
Counsel patients about drowsiness and monitor for excessive sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Frequently asked questions
Can I take Buprenorphine subdermal implant with Entacapone?
MediHelp rates the interaction as minor. Buprenorphine subdermal implant and Entacapone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Buprenorphine can cause sedation and dizziness, and entacapone may add to somnolence. The additive effect is generally modest with the low steady exposure from an implant.
How serious is the interaction between Buprenorphine subdermal implant and Entacapone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and monitor for excessive sedation.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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