Drug interactions
Buprenorphine subdermal implant + Flibanserin
Severity: Moderate
Buprenorphine subdermal implant and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin causes somnolence and sedation, and these effects add to those of buprenorphine. Concurrent use raises the risk of excessive sedation and impaired psychomotor function.
What this interaction means in plain words
Buprenorphine subdermal implant and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Counsel patients about sedation and avoid driving or hazardous activity; monitor for oversedation and reassess the need for flibanserin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Flibanserin?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin causes somnolence and sedation, and these effects add to those of buprenorphine. Concurrent use raises the risk of excessive sedation and impaired psychomotor function.
How serious is the interaction between Buprenorphine subdermal implant and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about sedation and avoid driving or hazardous activity; monitor for oversedation and reassess the need for flibanserin.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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