Drug interactions
Buprenorphine subdermal implant + Fluphenazine
Severity: Moderate
Buprenorphine subdermal implant and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine and buprenorphine both cause sedation, and each has some potential to prolong the QT interval. Together they may increase drowsiness, psychomotor impairment and, rarely, respiratory depression or arrhythmia risk. The effect is more relevant in patients with other risk factors.
What this interaction means in plain words
Buprenorphine subdermal implant and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid and antipsychotic effects plus possible additive QT prolongation.
What to do
Monitor for excessive sedation and respiratory depression, especially after dose changes. Check ECG and electrolytes in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Buprenorphine subdermal implant with Fluphenazine?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine and buprenorphine both cause sedation, and each has some potential to prolong the QT interval. Together they may increase drowsiness, psychomotor impairment and, rarely, respiratory depression or arrhythmia risk. The effect is more relevant in patients with other risk factors.
How serious is the interaction between Buprenorphine subdermal implant and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, especially after dose changes. Check ECG and electrolytes in patients with QT risk factors.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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