Drug interactions
Buprenorphine subdermal implant + Gemifloxacin
Severity: Moderate
Buprenorphine subdermal implant and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can have QT effects, though the implant delivers steady, low exposure. Combined with gemifloxacin there may be a modest additional risk of arrhythmia.
What this interaction means in plain words
Buprenorphine subdermal implant and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization.
What to do
Prefer a non-QT-prolonging antibiotic in patients with cardiac risk factors. If both are used, check an ECG and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Gemifloxacin?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can have QT effects, though the implant delivers steady, low exposure. Combined with gemifloxacin there may be a modest additional risk of arrhythmia.
How serious is the interaction between Buprenorphine subdermal implant and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antibiotic in patients with cardiac risk factors. If both are used, check an ECG and electrolytes.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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